当前文件夹为数据库目录，勿删SLU-PP-332 CAS No.: 303760-60-3 for regulating metabolism and exercise mimicry

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SLU-PP-332

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SLU-PP-332
303760-60-3
C18H14N2O2
290.32
98%
White or off-white powder
1kg/bag, 25kg/drum
Dietary Supplement Raw Material for regulating metabolism and exercise mimicry

Inquiry 

Product name	SLU-PP-332
Other name	SLU-PP-332； ꧒(E)-4-Hydroxy-N′(Naphthalen-2-Ylmethylene)Benzohydr🎶azide；4-Hydroxybenzoic acid 2-(2-naphꩵthalenylmethylene)hydrazide；
CAS No.	303760-60-3
Molecular formula	C18H14N2O2
Molecular weight	290.32
Purity	98%
Appearance	White or off-white powder
Packing	1kg/bag, 25kg/barrel
Application	Dietary Supplement Raw Material

 Product introduction

SLU-PP-332 is a novel small molecule compound that acts as a perifollicle estrogen receptor (ERR) agonist, primarily targeting ERRα, ERRβ, and ERRγ, with the strongest activation effect on ERRα (EC₅₀=98 nM). This compound activates the ERR signaling pathway by mimicking the metabolic regulation mechanisms of exercise, thereby modulating energy metabolism, mitochondrial function, and muscle endurance.

 Feature

(1)Mechanism of action: activate ERRα/β/γ, upregulate fatty acid oxidation (FAO) and mitochondrial respiration related genes, promote fat breakdown for energy supply, reduce fat accumulation, enhance skeletal muscle mitochondrial function, improve oxidative capacity and endurance, similar to the effect of aerobic training.
(2)Bioactivity: a) Animal model effects: Obese mice: after 28 days of medication, body weight decreased by 12%, and liver fat, cholesterol, and triglycerides were significantly reduced; normal mice: running time increased by 70%, distance increased by 45%, without affecting appetite or voluntary movement. b) Safety: no serious side effects were observed in preclinical studies.
(3)Phyꦇsical and chemica♛l properties: white to white solid, soluble in DMSO (75 mg/mL) and ethanol, insoluble in water; should be stored in the dark.

 Applications

SLU-PP-332 achieves fat loss and blood glucose regulation by promoting fat oxidation and improving insulin sensitivity; it improves non-alcoholic fatty liver disease (NAFLD), reducing liver fat content; provides metabolic support for individuals who cannot exercise, maintaining muscle mass and function; reduces muscle loss during the fat loss process; and has broad prospects in the areas of fat loss, endurance enhancement, and metabolic improvement.

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